Coursera Finding Hidden Messages in DNA (Bioinformatics I)

University of California, San Diego via Coursera

  • Overview
  1. Coursera
    Platform:
    Coursera
    Provider:
    University of California, San Diego
    Effort:
    4-10 hours a week
    Length:
    5 weeks
    Language:
    English
    Credentials:
    Paid Certificate Available
    Part of:
    Bioinformatics Specialization
    Overview
    This course begins a series of classes illustrating the power of computing in modern biology. Please join us on the frontier of bioinformatics to look for hidden messages in DNA without ever needing to put on a lab coat.

    In the first half of the course, we investigate DNA replication, and ask the question, where in the genome does DNA replication begin? We will see that we can answer this question for many bacteria using only some straightforward algorithms to look for hidden messages in the genome.

    In the second half of the course, we examine a different biological question, when we ask which DNA patterns play the role of molecular clocks. The cells in your body manage to maintain a circadian rhythm, but how is this achieved on the level of DNA? Once again, we will see that by knowing which hidden messages to look for, we can start to understand the amazingly complex language of DNA. Perhaps surprisingly, we will apply randomized algorithms, which roll dice and flip coins in order to solve problems.

    Finally, you will get your hands dirty and apply existing software tools to find recurring biological motifs within genes that are responsible for helping Mycobacterium tuberculosis go "dormant" within a host for many years before causing an active infection.

    Syllabus
    • Week 1: Welcome!
    • Week 2: Finding Replication Origins
    • Week 3: Hunting for Regulatory Motifs
    • Week 4: How Rolling Dice Helps Us Find Regulatory Motifs
    • Week 5: Bioinformatics Application Challenge

    Taught by
    Pavel Pevzner and Phillip Compeau

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