1. This course is part of the Bioinformatics Specialisation Program in the Health Science Degree Path.
    Click here to see all Bioinformatics courses

Required Comparing Genes, Proteins, and Genomes (Bioinformatics III)

By University of California San Diego via Coursera (42 Hours)

  • Overview
  1. MoocLab
    COURSE DESCRIPTION
    Once we have sequenced genomes in the previous course, we would like to compare them to determine how species have evolved and what makes them different.

    In the first half of the course, we will compare two short biological sequences, such as genes (i.e., short sequences of DNA) or proteins. We will encounter a powerful algorithmic tool called dynamic programming that will help us determine the number of mutations that have separated the two genes/proteins.

    In the second half of the course, we will "zoom out" to compare entire genomes, where we see large scale mutations called genome rearrangements, seismic events that have heaved around large blocks of DNA over millions of years of evolution. Looking at the human and mouse genomes, we will ask ourselves: just as earthquakes are much more likely to occur along fault lines, are there locations in our genome that are "fragile" and more susceptible to be broken as part of genome rearrangements? We will see how combinatorial algorithms will help us answer this question.

    Finally, you will learn how to apply popular bioinformatics software tools to solve problems in sequence alignment, including BLAST.

    Length: 6 Weeks
    Effort: 4-10 hours per week
    Price: FREE (Add a verified certificate for £36/month)
    Provider: University of California San Diego via Coursera
    Subject: Bioinformatics
    Level: Introductory
    Languages: English
    Instructors: Pavel Pevzner, Phillip Compeau and Nikolay Vyahhi

Share This Page



  1. This site uses cookies to help personalise content, tailor your experience and to keep you logged in if you register.
    By continuing to use this site, you are consenting to our use of cookies.
    Dismiss Notice